Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Skin Photoaging
Xinru Hu, Shuang Du, Meng Chen, Hao Yang, Jia He, Lei Zhang, Bowen Tan, Tao Wu, Xi Duan · 2024
Read Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Skin Photoaging by Xinru Hu, Shuang Du, Meng Chen, Hao Yang, Jia He, Lei Zhang, Bowen Tan, Tao Wu, Xi Duan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11662644.txt.
Description
Xinru Hu and co-authors combine single-cell and bulk gene data to uncover the molecular machinery of skin photoaging in a 2024 study. Sun-driven skin aging mixes genetic and environmental causes, and its exact drivers stay murky.
Public gene profiles from photoaged skin fed single-cell mapping and cell-chat analysis. A shrinkage regression built predictive models, and enrichment tools traced what the key genes do. Three genes stood out as central players, joined by immune cell links and a microRNA control network. Drug prediction on the co-expression web suggested treatment targets. Lab checks in living tissue confirmed the key genes, immune infiltration patterns, and a role for a major energy-sensing pathway. The work nominates fresh leads against sun-aged skin.
Catalog record
| CREATOR | Xinru Hu, Shuang Du, Meng Chen, Hao Yang, Jia He, Lei Zhang, Bowen Tan, Tao Wu, Xi Duan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |