Procoagulant platelet activation promotes venous thrombosis∗
Rainer Kaiser, Robin Dewender, Maité Mulkers, Julia Stermann, Dario Rossaro, Lea Di Fina, Lukas Li, Christoph Gold, Michael Schmid, Lily Kääb, Luke Eivers, Sezer Akgöl, Keyang Yue, Lisa Kammerer, Quentin Loew, Afra Anjum, Raphael Escaig, Anastassia Akhalkatsi, Lisa Laun, Jan Kranich, Thomas Brocker, · 2024
Read Procoagulant platelet activation promotes venous thrombosis∗ by Rainer Kaiser, Robin Dewender, Maité Mulkers, Julia Stermann, Dario Rossaro, Lea Di Fina, Lukas Li, Christoph Gold, Michael Schmid, Lily Kääb, Luke Eivers, Sezer Akgöl, Keyang Yue, Lisa Kammerer, Quentin Loew, Afra Anjum, Raphael Escaig, Anastassia Akhalkatsi, Lisa Laun, Jan Kranich, Thomas Brocker, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11662225.txt.
Description
Rainer Kaiser and a large team show that procoagulant platelet activation drives venous thrombosis, in work from 2024. Standard antiplatelet drugs barely prevent venous clots, so patients rely on anticoagulants with their bleeding risks. The team found raised levels of procoagulant platelets in the blood and clots of patients with deep vein thrombosis and lung emboli, and inside mouse clots as well.
Mice lacking key activation pathways in platelets resisted flow-driven venous clots. A licensed carbonic anhydrase drug, methazolamide, cut platelet procoagulant activity and shrank mouse thrombi without harming normal clotting after injury. The authors propose platelet activation as a safer drug target for venous disease.
Catalog record
| CREATOR | Rainer Kaiser, Robin Dewender, Maité Mulkers, Julia Stermann, Dario Rossaro, Lea Di Fina, Lukas Li, Christoph Gold, Michael Schmid, Lily Kääb, Luke Eivers, Sezer Akgöl, Keyang Yue, Lisa Kammerer, Quentin Loew, Afra Anjum, Raphael Escaig, Anastassia Akhalkatsi, Lisa Laun, Jan Kranich, Thomas Brocker, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |