Stable developmental patterns of gene expression without morphogen gradients
Maciej Majka, Nils B. Becker, Pieter Rein ten Wolde, Marcin Zagorski, Thomas R. Sokolowski · 2024
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Description
Maciej Majka and co-authors study how gene patterns stay stable in a developing embryo in a 2024 paper. Early patterns are set by chemical gradients. Later, those gradients fade, leaving the pattern exposed to cellular noise. Yet patterns in many systems stay stable and repeatable for long spans.
Using a simple embryo model with a stripe pattern, the team combined simulations with a sampling method and a stability theory. Weak repression between neighboring domains, tuned to an optimal level, extended pattern life by orders of magnitude. Strong repression between farther domains also played a role in the design.
Catalog record
| CREATOR | Maciej Majka, Nils B. Becker, Pieter Rein ten Wolde, Marcin Zagorski, Thomas R. Sokolowski |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |