Tubastrine, an antioxidant molecule from Tubastraea tagusensis sun coral, in the reversion of oxidative stress and neuron's death induced by Aβ42
Amanda G Silva, João Vitor Cerávolo Rostirola, Filipe Duo Speri, Juliana Guanaes Pina, Marcelo V Kitahara, Giovanna B Longato, Juliana M Sciani · 2024
Read Tubastrine, an antioxidant molecule from Tubastraea tagusensis sun coral, in the reversion of oxidative stress and neuron's death induced by Aβ42 by Amanda G Silva, João Vitor Cerávolo Rostirola, Filipe Duo Speri, Juliana Guanaes Pina, Marcelo V Kitahara, Giovanna B Longato, Juliana M Sciani (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11661463.txt.
Description
Amanda Silva and six colleagues isolate a protective molecule from a sun coral and test it against amyloid damage in neuron-like cells, in a 2024 study. Alzheimer's disease involves amyloid-beta clumps that drive oxidative stress and kill neurons. The team fractionated coral extracts by antioxidant activity until one pure compound remained, identified as tubastrine.
Cells exposed to the toxic amyloid fragment died at high rates and carried far more reactive oxygen. Adding tubastrine cut the death rate, pulled the reactive oxygen share down from 65 to 50 percent, and restored the cells' antioxidant power to near normal. The authors present tubastrine as a candidate worth further study for Alzheimer's therapy.
Catalog record
| CREATOR | Amanda G Silva, João Vitor Cerávolo Rostirola, Filipe Duo Speri, Juliana Guanaes Pina, Marcelo V Kitahara, Giovanna B Longato, Juliana M Sciani |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |