Effect of a SARS-CoV-2 Protein Fragment on the Amyloidogenic Propensity of Human Islet Amyloid Polypeptide
Marvin Bilog, Jennifer Cersosimo, Iliana Vigil, Ruel Z. B. Desamero, Adam A. Profit · 2024
Read Effect of a SARS-CoV-2 Protein Fragment on the Amyloidogenic Propensity of Human Islet Amyloid Polypeptide by Marvin Bilog, Jennifer Cersosimo, Iliana Vigil, Ruel Z. B. Desamero, Adam A. Profit (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11660541.txt.
Description
Marvin Bilog and co-authors published this 2024 study on a possible link between COVID-19 and type 2 diabetes. Infection with the virus has been tied to a higher risk of the disease. One proposed route runs through a hormone called amylin, which can clump into harmful amyloid in the pancreas.
The team studied a short fragment of a viral protein, named SK9, that earlier computer work said could steady the normal shape of amylin. Using docking, simulations, and lab tests, they show SK9 binds two short clumping-prone pieces of amylin. Better still, the fragment stops those pieces from assembling into clumps. The findings support one concrete path by which the virus might stir diabetes risk.
Catalog record
| CREATOR | Marvin Bilog, Jennifer Cersosimo, Iliana Vigil, Ruel Z. B. Desamero, Adam A. Profit |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |