Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8+CD69+ T cells
Shichuan Tang, Ruijing Tang, Geng Chen, Da Zhang, Kongying Lin, Huan Yang, Jun Fu, Yutong Guo, Fangzhou Lin, Xiuqing Dong, Tingfeng Huang, Jie Kong, Xiaowei Yin, Aimin Ge, Qizhu Lin, Ming Wu, Xiaolong Liu, Yongyi Zeng, Zhixiong Cai · 2024
Read Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8+CD69+ T cells by Shichuan Tang, Ruijing Tang, Geng Chen, Da Zhang, Kongying Lin, Huan Yang, Jun Fu, Yutong Guo, Fangzhou Lin, Xiuqing Dong, Tingfeng Huang, Jie Kong, Xiaowei Yin, Aimin Ge, Qizhu Lin, Ming Wu, Xiaolong Liu, Yongyi Zeng, Zhixiong Cai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11660327.txt.
Description
Shichuan Tang and co-authors report a study from two thousand twenty-four on a personalized gel vaccine against cancer that has spread to the liver. Liver metastases resist immune attack and lack good treatments. Patient data showed they survive worse and host few killer T cells but many suppressor cells.
The vaccine packs tumor-specific peptides, picked from the patient's own cancer, into a hyaluronic acid gel with two immune boosters. Unlike loose peptide shots, the gel holds the dose in place. In mouse models of liver metastasis, the gel plus a double blockade of two immune brakes produced strong antitumor responses. The effect ran through activating a marked subset of killer T cells inside the tumors. The authors stress the design's clinical feasibility.
Catalog record
| CREATOR | Shichuan Tang, Ruijing Tang, Geng Chen, Da Zhang, Kongying Lin, Huan Yang, Jun Fu, Yutong Guo, Fangzhou Lin, Xiuqing Dong, Tingfeng Huang, Jie Kong, Xiaowei Yin, Aimin Ge, Qizhu Lin, Ming Wu, Xiaolong Liu, Yongyi Zeng, Zhixiong Cai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |