Molecular Characteristics of Sweet Syndrome: A Systematic Review
Laura Calabrese, Maurizio Romagnuolo, Martina D'Onghia, Pietro Rubegni, Angelo V Marzano, Chiara Moltrasio · 2024
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Description
Sweet syndrome erupts as tender red plaques with fever, driven by crowds of white blood cells flooding the skin, yet its molecular triggers remain murky. Laura Calabrese and co-authors systematically reviewed studies that probed the syndrome at the molecular level, following standard review guidelines. From more than three thousand records they kept twenty-two papers covering 202 patients, mostly skin biopsies.
Across the syndrome's forms, overactive neutrophils and their abnormal growth formed the common thread. One alarm pathway, centred on interleukin-1, ran hot only in a subset of patients. Adaptive immunity also played a part, with another signalling axis, interleukin-17, looking prominent. The authors say the map of mechanisms is rich but incomplete, and they hope it guides targeted treatments for this rare disease.
Catalog record
| CREATOR | Laura Calabrese, Maurizio Romagnuolo, Martina D'Onghia, Pietro Rubegni, Angelo V Marzano, Chiara Moltrasio |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |