Investigation of the effects of a new transdermal formulation of systemic diclofenac on the upper gastrointestinal mucosa in patients with low back pain: A comparative study with oral diclofenac
Hiroyuki Fukase, Seiji Futagami, Takatsugu Yamamoto, Tatsuhiro Masaoka, Takaaki Terahara, Koji Okawa, Yusuke Tanaka, Tsuyoshi Mita · 2024
Read Investigation of the effects of a new transdermal formulation of systemic diclofenac on the upper gastrointestinal mucosa in patients with low back pain: A comparative study with oral diclofenac by Hiroyuki Fukase, Seiji Futagami, Takatsugu Yamamoto, Tatsuhiro Masaoka, Takaaki Terahara, Koji Okawa, Yusuke Tanaka, Tsuyoshi Mita (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11660207.txt.
Description
Painkillers in the diclofenac family ease back pain but often injure the stomach when swallowed. A skin patch that sends the same drug through the blood could spare the gut lining. The authors of a 2024 Japanese study test that idea in patients with low back pain. Sixty patients were split evenly between the patch at a higher daily dose and the tablet at a standard dose for two weeks. A camera exam of the stomach and upper bowel followed.
Ulcers or erosions appeared in about 27 percent of the patch group against 86 percent of the tablet group. No side effects appeared with the patch, while a fifth of tablet users reported mild ones. The authors back the patch as the gentler route.
Catalog record
| CREATOR | Hiroyuki Fukase, Seiji Futagami, Takatsugu Yamamoto, Tatsuhiro Masaoka, Takaaki Terahara, Koji Okawa, Yusuke Tanaka, Tsuyoshi Mita |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |