Gene expression levels associated with impaired immune response and increased proliferation could serve as biomarkers for women following cervical cancer screening programmes
Irene T. Ovestad, Ingvild Dalen, Kristiane Soreng, Saleha Akbari, Morten Lapin, Emiel AM Janssen, Marie Austdal, Ane Cecilie Munk, Einar Gudlaugsson · 2024
Read Gene expression levels associated with impaired immune response and increased proliferation could serve as biomarkers for women following cervical cancer screening programmes by Irene T. Ovestad, Ingvild Dalen, Kristiane Soreng, Saleha Akbari, Morten Lapin, Emiel AM Janssen, Marie Austdal, Ane Cecilie Munk, Einar Gudlaugsson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11659148.txt.
Description
Irene Ovestad and colleagues searched in two thousand twenty-four for gene markers that sort women after cervical screening into who needs a biopsy soon. Virus type alone does not tell which infections will progress, since immune response matters too. Comparing stubborn advanced lesions with normal tissue, they profiled immune-related gene activity.
Four genes stood out: two immune markers and two tumor markers. Testing in a much larger biopsy group checked whether their activity levels separate advanced lesions from normal and milder tissue. Combined with virus risk class, such markers could sharpen follow-up decisions. Screening programs gain a path to fewer missed cancers and fewer needless biopsies.
Catalog record
| CREATOR | Irene T. Ovestad, Ingvild Dalen, Kristiane Soreng, Saleha Akbari, Morten Lapin, Emiel AM Janssen, Marie Austdal, Ane Cecilie Munk, Einar Gudlaugsson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |