Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study
Bingren Hu, Yi Yang, Jiangqiao Yao, Ganglian Lin, Qikuan He, Zhiyuan Bo, Zhewei Zhang, Anlvna Li, Yi Wang, Gang Chen, Yunfeng Shan · 2024
Read Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study by Bingren Hu, Yi Yang, Jiangqiao Yao, Ganglian Lin, Qikuan He, Zhiyuan Bo, Zhewei Zhang, Anlvna Li, Yi Wang, Gang Chen, Yunfeng Shan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11659115.txt.
Description
Bingren Hu and co-authors probe how gut microbes link hepatitis B infection to liver cancer. The virus is a known driver of this cancer, yet the gut's part in that chain was murky. The team asks whether microbes carry part of the effect, and whether they change its strength.
More than six hundred patients with chronic liver disease or liver cancer gave stool samples for gene sequencing. After matching, one hundred forty-seven pairs entered the close analysis. Two microbe groups carried part of the virus effect on cancer, while five others bent its strength up or down. Virus load, a tumor marker, and liver scores each stood as solo risk factors. Machine learning models built on microbe data sorted cancer cases with strong accuracy. Gut checks may thus join standard tools for spotting high-risk patients early.
Catalog record
| CREATOR | Bingren Hu, Yi Yang, Jiangqiao Yao, Ganglian Lin, Qikuan He, Zhiyuan Bo, Zhewei Zhang, Anlvna Li, Yi Wang, Gang Chen, Yunfeng Shan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |