A Pax3 lineage gives rise to transient haematopoietic progenitors
Giovanni Canu, Rosamaria Correra, Guillermo Diez-Pinel, Raphaël F. P. Castellan, Laura Denti, Alessandro Fantin, Christiana Ruhrberg · 2024
Read A Pax3 lineage gives rise to transient haematopoietic progenitors by Giovanni Canu, Rosamaria Correra, Guillermo Diez-Pinel, Raphaël F. P. Castellan, Laura Denti, Alessandro Fantin, Christiana Ruhrberg (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11658681.txt.
Description
Giovanni Canu and co-authors find an odd source of young blood cells in mouse embryos, in work from 2024. Cells marked by the Pax3 gene were known to build muscle, skin, and some vessel lining. Blood-forming roots were thought to sit in other embryo layers that lack Pax3. Whether Pax3-line cells join the blood pool was not known.
The team found Pax3-line cells in the fetal liver and fetal blood with clear blood-starter traits. Those cells could grow into both white and red blood lines. The authors urge study of this fleet source for what it says about normal blood growth. Flaws in these cells may also seed blood cancers.
Catalog record
| CREATOR | Giovanni Canu, Rosamaria Correra, Guillermo Diez-Pinel, Raphaël F. P. Castellan, Laura Denti, Alessandro Fantin, Christiana Ruhrberg |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |