Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting
Zifei Wu, Xie Huang, Chuan Wu, Yan Zhou, Mingquan Gao, Shenglin Luo, Qiang Xiang, Weidong Wang, Rong Li · 2024
Read Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting by Zifei Wu, Xie Huang, Chuan Wu, Yan Zhou, Mingquan Gao, Shenglin Luo, Qiang Xiang, Weidong Wang, Rong Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11658457.txt.
Description
Wu and eight co-authors design dyes to boost radiotherapy for kidney cancer, in work from twenty twenty-four. Renal cell carcinoma resists radiation, so higher doses or sensitizers are needed. A dye that gathers in tumor cell mitochondria could make radiation hit harder where it matters.
Their indocyanine dyes carry polyethylene glycol chains of varied lengths on one side, making them water and fat friendly at once. That balance drives them to mitochondria, the cell power plants. Damage there amplifies radiation effects. The chemistry aims for stronger tumor kill without raising dose to healthy kidney tissue.
Catalog record
| CREATOR | Zifei Wu, Xie Huang, Chuan Wu, Yan Zhou, Mingquan Gao, Shenglin Luo, Qiang Xiang, Weidong Wang, Rong Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |