Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36γ transcription in colorectal cancer
Yan Hu, Ze-Rong Cai, Ren-Ze Huang, De-Shen Wang, Huai-Qiang Ju, Dong-Liang Chen · 2024
Read Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36γ transcription in colorectal cancer by Yan Hu, Ze-Rong Cai, Ren-Ze Huang, De-Shen Wang, Huai-Qiang Ju, Dong-Liang Chen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11658269.txt.
Description
Yan Hu and co-authors trace how a circular RNA helps colorectal cancer grow and dodge immune therapy. Their 2024 paper centers on circPHLPP2, a ring-shaped RNA found at high levels in patients whose tumors resist anti-PD-1 treatment. Most patients with this cancer gain little from that therapy, and the reasons have stayed murky.
Lab tests show the ring boosts cell growth and tumor formation. The team traced its path: the molecule binds a protein partner, which in turn switches on a signal gene tied to immune control. Screens, sequencing, and pull-down assays built that chain step by step. Silencing the ring could in principle reopen the tumor to immune attack, and its level might flag resistant patients early. The work opens a fresh angle on immune evasion in this cancer.
Catalog record
| CREATOR | Yan Hu, Ze-Rong Cai, Ren-Ze Huang, De-Shen Wang, Huai-Qiang Ju, Dong-Liang Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |