Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance
Zhuangjie Lin, Qiaorui Yao, Keyuan Lai, Kehua Jiao, Xianying Zeng, Guanxiong Lei, Tongwen Zhang, Hongsheng Dai · 2024
Read Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance by Zhuangjie Lin, Qiaorui Yao, Keyuan Lai, Kehua Jiao, Xianying Zeng, Guanxiong Lei, Tongwen Zhang, Hongsheng Dai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11658101.txt.
Description
Eight researchers report a study from two thousand twenty-four on gene drives built inside a virus. A gene drive is a genetic package that copies itself into the next generation, and labs hope to use drives against harmful species. A known weakness is resistance: cell repair can patch the cut and block the drive.
The team built drives with two different cutting systems in a fast-growing herpes virus. Both drives spread through the virus population and hit their target sites. The newer system, Cas12f1, is known for causing fewer stray mutations at its target. It spread about as well as the older system while drawing minimal resistance.
Catalog record
| CREATOR | Zhuangjie Lin, Qiaorui Yao, Keyuan Lai, Kehua Jiao, Xianying Zeng, Guanxiong Lei, Tongwen Zhang, Hongsheng Dai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |