The impact of high-risk cytogenetic abnormalities in extramedullary multiple myeloma in the era of novel agents: insights from a multicenter study
Dong Liang, Yurong Yan, Shenrui Bai, Weiling Xu, Qiaoli Wang, Demei Feng, Min Zeng, Xiaomiao Nie, Yuan Feng, Xiaoqin Chen, Zhongjun Xia, Yang Liang, Fengyan Jin, Hua Wang · 2024
Read The impact of high-risk cytogenetic abnormalities in extramedullary multiple myeloma in the era of novel agents: insights from a multicenter study by Dong Liang, Yurong Yan, Shenrui Bai, Weiling Xu, Qiaoli Wang, Demei Feng, Min Zeng, Xiaomiao Nie, Yuan Feng, Xiaoqin Chen, Zhongjun Xia, Yang Liang, Fengyan Jin, Hua Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11657861.txt.
Description
Multiple myeloma sometimes escapes the bone marrow and grows in soft tissues, a form called extramedullary disease with a poorer outlook. Dong Liang and co-authors asked in 2024 whether high-risk chromosome abnormalities sharpen that risk further, using the largest such dataset in China: 371 patients treated in the era of modern drugs.
Patients carrying one high-risk abnormality, and still more those carrying two or more, survived significantly less long and progressed sooner than patients with none. One change, extra copies of a region called 1q21, predicted poor outcomes on its own. Antibody therapy built on CD38 and single stem-cell transplants failed to rescue the group with two or more abnormalities. Blood markers and disease outside bone also predicted worse survival. The authors argue the count of such abnormalities should guide treatment choices and prognosis talks.
Catalog record
| CREATOR | Dong Liang, Yurong Yan, Shenrui Bai, Weiling Xu, Qiaoli Wang, Demei Feng, Min Zeng, Xiaomiao Nie, Yuan Feng, Xiaoqin Chen, Zhongjun Xia, Yang Liang, Fengyan Jin, Hua Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |