Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study
Xingchen Zhou, Guixue Hou, Xin Wang, Zhaoyi Peng, Xiaoming Yin, Jing Yang, Shan Wang, Yayi He, Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Yanan Wang, Liang Lin, Bingyin Shi, Mingqian He · 2024
Read Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study by Xingchen Zhou, Guixue Hou, Xin Wang, Zhaoyi Peng, Xiaoming Yin, Jing Yang, Shan Wang, Yayi He, Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Yanan Wang, Liang Lin, Bingyin Shi, Mingqian He (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11657842.txt.
Description
Xingchen Zhou and a large team search blood serum for markers of diabetic retinopathy in type 2 diabetes. The eye disease is a major complication of diabetes and a cause of vision loss and blindness. Standard risk factors such as HbA1c do not explain all cases, so new markers are needed. The team ran untargeted and targeted metabolomic studies with mass spectrometry on patient serum.
The discovery set held 39 patients with retinopathy and 39 without, and a validation set held 95 in each group. Receiver operating characteristic analysis judged how well each metabolite separated the groups. Regression models then checked links between metabolite levels and the presence of retinopathy.
Catalog record
| CREATOR | Xingchen Zhou, Guixue Hou, Xin Wang, Zhaoyi Peng, Xiaoming Yin, Jing Yang, Shan Wang, Yayi He, Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Yanan Wang, Liang Lin, Bingyin Shi, Mingqian He |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |