Differential somatic coding variant landscapes between laser microdissected luminal epithelial cells from canine mammary invasive ductal solid carcinoma and comedocarcinoma
Vivi Deckwirth, Sruthi Hundi, Marjo K Hytönen, Sari Hannula, Pekka Ellonen, Pia Björkenheim, Antti Sukura, Hannes Lohi · 2024
Read Differential somatic coding variant landscapes between laser microdissected luminal epithelial cells from canine mammary invasive ductal solid carcinoma and comedocarcinoma by Vivi Deckwirth, Sruthi Hundi, Marjo K Hytönen, Sari Hannula, Pekka Ellonen, Pia Björkenheim, Antti Sukura, Hannes Lohi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11657561.txt.
Description
Vivi Deckwirth and co-authors present a 2024 study comparing the mutation landscapes of two dog breast cancers. Dogs develop mammary tumors much like human breast cancers, and two subtypes mirror human forms. The team isolated tiny groups of cancer cells by laser from frozen tissue of a single dog.
One subtype, comedocarcinoma, carried six times more coding variants than the solid carcinoma. The solid type's changes hit cell adhesion genes and growth pathways. Unaffected cells from the same dog served as controls. The genomic results were set beside tissue features and human breast cancer data from major databases. The authors argue the comparison sharpens both veterinary care and the dog's value as a model of human disease.
Catalog record
| CREATOR | Vivi Deckwirth, Sruthi Hundi, Marjo K Hytönen, Sari Hannula, Pekka Ellonen, Pia Björkenheim, Antti Sukura, Hannes Lohi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |