Comprehensive analysis of lysine lactylation and its potential biological significance in clear cell renal cell carcinoma
Bangbei Wan, Yuan Huang, Binghao Gong, Yaohui Zeng, Cai Lv · 2024
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Description
Bangbei Wan and four co-authors map a protein mark in kidney cancer in a study from two thousand twenty-four. Lactylation, a lactate-based tag on lysine, helps rewire tumor metabolism. Its spread in clear cell kidney cancer was unknown.
Twelve tumor and nearby normal samples from six patients were compared by mass spectrometry and blotting. The screen found two hundred thirty-nine proteins carrying the tag at four hundred forty-one sites. Most sat in the cytoplasm or mitochondria. The tagged proteins clustered in energy pathways: sugar breakdown, fat burning, and the citrate cycle. Twenty hub proteins stood out in interaction networks. The authors propose these marks as candidate drug targets, while noting lab proof is still needed.
Catalog record
| CREATOR | Bangbei Wan, Yuan Huang, Binghao Gong, Yaohui Zeng, Cai Lv |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |