Prion protein regulates invasiveness in glioblastoma stem cells
Mariana B Prado, Bárbara P Coelho, Rebeca P Iglesia, Rodrigo N Alves, Jacqueline M Boccacino, Camila F L Fernandes, Maria Isabel Melo-Escobar, Shamini Ayyadhury, Mario C Cruz, Tiago G Santos, Flávio H Beraldo, Jue Fan, Frederico M Ferreira, Helder I Nakaya, Marco A M Prado, Vania F Prado, Martin L D · 2024
Read Prion protein regulates invasiveness in glioblastoma stem cells by Mariana B Prado, Bárbara P Coelho, Rebeca P Iglesia, Rodrigo N Alves, Jacqueline M Boccacino, Camila F L Fernandes, Maria Isabel Melo-Escobar, Shamini Ayyadhury, Mario C Cruz, Tiago G Santos, Flávio H Beraldo, Jue Fan, Frederico M Ferreira, Helder I Nakaya, Marco A M Prado, Vania F Prado, Martin L D (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11657363.txt.
Description
Mariana Prado and co-authors probe a surface protein that helps brain tumor stem cells spread. Their 2024 study treats glioblastoma, a fast and deadly brain cancer fed by stem-like cells. The protein, best known from prion disease, sits on the cell surface and touches many partners that steer tumor growth.
Gene edits that remove the protein reshaped gene use in two tumor cell lines, the team reports. Cells without it invaded less, moved less, grew slower, and renewed themselves less. A key stem marker lost its place and level in those cells. Patient tumor data echo the lab pattern. The protein thus looks like a target worth testing for this cancer.
Catalog record
| CREATOR | Mariana B Prado, Bárbara P Coelho, Rebeca P Iglesia, Rodrigo N Alves, Jacqueline M Boccacino, Camila F L Fernandes, Maria Isabel Melo-Escobar, Shamini Ayyadhury, Mario C Cruz, Tiago G Santos, Flávio H Beraldo, Jue Fan, Frederico M Ferreira, Helder I Nakaya, Marco A M Prado, Vania F Prado, Martin L D |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |