Functional omics of ORP7 in primary endothelial cells
Juuso H Taskinen, Minna Holopainen, Hanna Ruhanen, Miesje van der Stoel, Reijo Käkelä, Elina Ikonen, Salla Keskitalo, Markku Varjosalo, Vesa M Olkkonen · 2024
Read Functional omics of ORP7 in primary endothelial cells by Juuso H Taskinen, Minna Holopainen, Hanna Ruhanen, Miesje van der Stoel, Reijo Käkelä, Elina Ikonen, Salla Keskitalo, Markku Varjosalo, Vesa M Olkkonen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656939.txt.
Description
Juuso Taskinen and co-authors run a hypothesis-free multi-omics study of ORP7, a lipid-binding protein, in primary endothelial cells. Their 2024 paper deals with a family member whose functions have stayed elusive.
Other proteins in the family are well characterized, but ORP7 is not. It sits at membranes of the endoplasmic reticulum and cell surface, and interacts with autophagy-related proteins. Suggested roles include cholesterol efflux and macroautophagy. The team blocked ORP7 chemically and measured the transcriptome and the lipidome. A proximity labeling method mapped its interaction partners. Working in primary human cells, rather than a cell line, keeps the findings close to real vessel biology.
Catalog record
| CREATOR | Juuso H Taskinen, Minna Holopainen, Hanna Ruhanen, Miesje van der Stoel, Reijo Käkelä, Elina Ikonen, Salla Keskitalo, Markku Varjosalo, Vesa M Olkkonen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |