The antibacterial and anti-biofilm effects of novel synthetized nitroimidazole compounds against methicillin-resistant Staphylococcus aureus and carbapenem-resistant Escherichia coli and Klebsiella pneumonia in vitro and in silico
Elham Zarenezhad, Esmaeil Behmard, Raziyeh Karami, Somayeh Behrouz, Mahrokh Marzi, Abdolmajid Ghasemian, Mohammad Navid Soltani Rad · 2024
Read The antibacterial and anti-biofilm effects of novel synthetized nitroimidazole compounds against methicillin-resistant Staphylococcus aureus and carbapenem-resistant Escherichia coli and Klebsiella pneumonia in vitro and in silico by Elham Zarenezhad, Esmaeil Behmard, Raziyeh Karami, Somayeh Behrouz, Mahrokh Marzi, Abdolmajid Ghasemian, Mohammad Navid Soltani Rad (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656861.txt.
Description
Elham Zarenezhad and co-authors synthesize new nitroimidazole compounds and test them against drug resistant bacteria, in work from twenty twenty-four. Resistance and biofilm growth make many infections hard to clear. The team made fifteen compounds by a copper aided coupling route.
Tests covered resistant staph and drug strong gut bacteria from standard and patient strains. One compound beat a classic drug by wide margins on several strains at very low doses. Others topped the classic drug against the resistant gut types. Ten compounds also fought biofilms. Computer docking checks backed the lab results. The authors call for animal and clinical follow up before any medical use.
Catalog record
| CREATOR | Elham Zarenezhad, Esmaeil Behmard, Raziyeh Karami, Somayeh Behrouz, Mahrokh Marzi, Abdolmajid Ghasemian, Mohammad Navid Soltani Rad |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |