An hiPSC-CM approach for electrophysiological phenotyping of a patient-specific case of short-coupled TdP
Willem B van Ham, Esmeralda E M Meijboom, Merel L Ligtermoet, Jantine Monshouwer-Kloots, Anneline S J M te Riele, Folkert W Asselbergs, Eva van Rooij, Mimount Bourfiss, Toon A B van Veen · 2024
Read An hiPSC-CM approach for electrophysiological phenotyping of a patient-specific case of short-coupled TdP by Willem B van Ham, Esmeralda E M Meijboom, Merel L Ligtermoet, Jantine Monshouwer-Kloots, Anneline S J M te Riele, Folkert W Asselbergs, Eva van Rooij, Mimount Bourfiss, Toon A B van Veen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656816.txt.
Description
Willem van Ham and co-authors grow heart cells from a patient's own stem cells to study her rhythm disorder, in a 2024 paper. The woman, twenty-six and healthy, survived a cardiac arrest during a fever, yet scans and gene tests found no cause. A device was implanted, and it later stopped a second arrest under like conditions. A fresh review named the disorder as a short-coupled form of torsades de pointes, and she was started on a drug.
The team reprogrammed her cells into heart muscle cells and compared them with cells from a matched healthy donor. Dyes that track voltage and calcium let them watch cell firing at normal and fever heat. Gene activity checks hunted for what sets her cells apart. The setup gives a personal test bed for a rare disorder.
Catalog record
| CREATOR | Willem B van Ham, Esmeralda E M Meijboom, Merel L Ligtermoet, Jantine Monshouwer-Kloots, Anneline S J M te Riele, Folkert W Asselbergs, Eva van Rooij, Mimount Bourfiss, Toon A B van Veen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |