Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis
Xiaomin Zhang, Yanmei Zhang, Wei Du · 2024
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Description
Xiaomin Zhang, Yanmei Zhang, and Wei Du study whether ketamine can ease bone pain caused by breast cancer spread, in a paper from 2024. When breast cancer reaches bone, it drives the growth of cells that eat bone away, and the result is deep pain. Whether ketamine helps such pain has been debated for years.
The team treated two breast cancer cell lines with ketamine and checked their growth and spread traits. Cancer cells were also grown with bone precursor cells to watch the bone eating effect. Gene tools shifted three linked genes in the cancer cells to test their roles. Mice given cancer cells through the heart let the team study bone spread in a living body. Ketamine curbed the bone eating process in these tests.
Catalog record
| CREATOR | Xiaomin Zhang, Yanmei Zhang, Wei Du |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |