A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases
Hazel Leiva, Pamela L. Caro De Silva, Ron Painter, Van Thi Bich Le, Patricia Uychoco, Daniel Figueroa Paniagua, Michael Endres, Natalia Maltseva, Andrzej Joachimiak, Misty L. Kuhn · 2024
Read A Structurally Diverse Compound Screening Library to Identify Substrates for Diamine, Polyamine, and Related Acetyltransferases by Hazel Leiva, Pamela L. Caro De Silva, Ron Painter, Van Thi Bich Le, Patricia Uychoco, Daniel Figueroa Paniagua, Michael Endres, Natalia Maltseva, Andrzej Joachimiak, Misty L. Kuhn (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656603.txt.
Description
Hazel Leiva and co-authors screen a diverse compound library to learn what a family of acetylating enzymes truly accepts, in work from twenty twenty-four. These enzymes tag diamines and polyamines with acetyl groups in cells. Kin enzymes likely accept other amine-bearing compounds as well. Native targets beyond the classic polyamines remain poorly mapped. Seventeen enzymes from the family face a varied compound panel.
Compounds vary in chain length, inner amines, and extra chemical groups. Twelve enzymes acetylate at least one panel compound in tests. Some enzymes accept just one compound with strict selectivity. Others accept many compounds with broad promiscuity in the screen. Patterns pinpoint specific substrates worth deeper follow-up study. Cell roles for acetylated small molecules come into sharper focus. Enzyme naming by assumed substrate may need revision.
Catalog record
| CREATOR | Hazel Leiva, Pamela L. Caro De Silva, Ron Painter, Van Thi Bich Le, Patricia Uychoco, Daniel Figueroa Paniagua, Michael Endres, Natalia Maltseva, Andrzej Joachimiak, Misty L. Kuhn |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |