STAT5: Understanding the Biology of KRASG12D‐Driven Pancreatic Cancer
Kostas A Papavassiliou, Christos Adamopoulos, Athanasios G Papavassiliou · 2024
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Description
Kostas Papavassiliou, Christos Adamopoulos, and Athanasios Papavassiliou spotlight a signaling protein in pancreatic cancer in a 2024 review. The disease is found late in most cases and carries the worst survival of common cancers. One mutant gene, KRAS with a specific G12D change, drives much of it. The review reads the biology of a signal carrier, STAT5, inside that driven cancer.
Half of patients die within three months of diagnosis, so new angles are urgent. How STAT5 behaves with the mutant driver may expose a drug target or a marker of aggression. Reviews of this kind stake out the next experiments for a field that cannot afford to wander.
Catalog record
| CREATOR | Kostas A Papavassiliou, Christos Adamopoulos, Athanasios G Papavassiliou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |