C-X-C Motif Chemokine 12 Was Identified as a Potential Gene Target in the Treatment of Crohn’s Disease
Hongsai Hu, Rong He, Minji Liu, Hongbing Zhou, Lin Tan, Qiongjia Ai, Qian Wang, Luwei Zeng, Weiming Qu · 2024
Read C-X-C Motif Chemokine 12 Was Identified as a Potential Gene Target in the Treatment of Crohn’s Disease by Hongsai Hu, Rong He, Minji Liu, Hongbing Zhou, Lin Tan, Qiongjia Ai, Qian Wang, Luwei Zeng, Weiming Qu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656194.txt.
Description
Hongsai Hu and co-authors name a signaling gene as a possible drug target in Crohn's disease in this 2024 study. Crohn's disease flares and calms in cycles that are hard to control. New gene targets could give doctors more ways to calm the gut.
The team compared gene activity in healthy tissue and in active and quiet disease. Shared changed genes were screened through pathway and network analysis. One chemokine gene, CXCL12, stood out as a hub in the network. Its levels and test value were checked in the same data set. A hub gene can steer many disease steps at once. The finding gives drug researchers a concrete lead to test.
Catalog record
| CREATOR | Hongsai Hu, Rong He, Minji Liu, Hongbing Zhou, Lin Tan, Qiongjia Ai, Qian Wang, Luwei Zeng, Weiming Qu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |