STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions
Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan Hu · 2024
Read STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions by Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan Hu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656094.txt.
Description
Zhiruo Liu and co-authors trace a signaling switch behind post-stroke inflammation in a 2024 study. Brain immune cells start out calming after stroke, then turn hostile over days. What flips them was unknown, and that flip drives much of the later damage.
Single-cell data pointed to the STING pathway and its interferon signal rising with the hostile turn. Staining confirmed the timing in mouse stroke tissue. Constant debris eating by the cells seemed to trip the switch. A drug blocking STING stopped the turn, cut inflammation, and protected the brain. Behavior tests also favored treated mice. The authors propose STING blockade as a stroke therapy lead.
Catalog record
| CREATOR | Zhiruo Liu, Qin Qin, Shisi Wang, Xinmei Kang, Yuxin Liu, Lei Wei, Zhengqi Lu, Wei Cai, Mengyan Hu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |