Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice
Tatiana V Lipina, Huy Giang, Jonathan S Thacker, William C Wetsel, Marc G Caron, Jean Martin Beaulieu, Ali Salahpour, Amy J Ramsey · 2024
Read Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice by Tatiana V Lipina, Huy Giang, Jonathan S Thacker, William C Wetsel, Marc G Caron, Jean Martin Beaulieu, Ali Salahpour, Amy J Ramsey (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656026.txt.
Description
Tatiana Lipina and co-authors combine two antipsychotic drugs to reach the symptoms of schizophrenia that standard drugs miss. Their study appeared in 2024. Damage to one glutamate receptor type reproduces the full symptom range in mice, including flat affect and poor thinking. The team paired haloperidol, an older standard, with UNC9994, a cousin of aripiprazole tuned to use only one of the dopamine receptor's two signaling arms, the arrestin arm.
Mice with the receptor blocked chemically or genetically received the pair, and behavior plus brain signaling were tracked. The combination eased the induced symptoms beyond either drug's usual reach. The authors say splitting dopamine signaling by pathway may let old and new drugs cover for each other's blind spots.
Catalog record
| CREATOR | Tatiana V Lipina, Huy Giang, Jonathan S Thacker, William C Wetsel, Marc G Caron, Jean Martin Beaulieu, Ali Salahpour, Amy J Ramsey |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |