Identification of a pyroptosis-related prognostic model for colorectal cancer and validation of the core gene SPTBN5
Guangyao Li, Pingyu Wang, Xiangnan Feng, Yongxiang Li · 2024
Read Identification of a pyroptosis-related prognostic model for colorectal cancer and validation of the core gene SPTBN5 by Guangyao Li, Pingyu Wang, Xiangnan Feng, Yongxiang Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11656000.txt.
Description
Guangyao Li and co-authors report a 2024 study that builds a risk model for colorectal cancer from genes tied to a fiery form of cell death. That death mode, pyroptosis, is driven by inflammasomes in some cases and by other paths in others. Its link to colon cancer outcomes had been unclear.
The team compared 52 such genes in cancer and normal tissue and found 40 that differ. A statistical method then picked a core set and built a risk score for patients. The score split a national cohort into high-risk and low-risk groups with distinct immune profiles. One core gene, SPTBN5, was tested in lab work on colon cancer cells to confirm its role. The model offers a fresh way to forecast patient outcomes.
Catalog record
| CREATOR | Guangyao Li, Pingyu Wang, Xiangnan Feng, Yongxiang Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |