HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients
Giovanna Talarico, Andrea Franceschini, Alessandro Raveane, Paolo Falvo, Saveria Mazzara, Federica Melle, Giovanna Motta, Stefania Orecchioni, Annamaria Tenore, Giuliana Gregato, Claudia Poletti, Roberto Chiarle, Stefano Pileri, Patrizia Mancuso, Francesco Bertolini · 2024
Read HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients by Giovanna Talarico, Andrea Franceschini, Alessandro Raveane, Paolo Falvo, Saveria Mazzara, Federica Melle, Giovanna Motta, Stefania Orecchioni, Annamaria Tenore, Giuliana Gregato, Claudia Poletti, Roberto Chiarle, Stefano Pileri, Patrizia Mancuso, Francesco Bertolini (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655943.txt.
Description
Giovanna Talarico and co-authors search for gene markers that can tell apart patients with large granular lymphocytic leukemia who feel ill from those who do not. Published in 2024, the study covers a blood cancer whose course varies a lot: some patients have low white cell counts with no symptoms, while others face grave infections. Tools to predict outcome are lacking.
The team tested gene activity in 27 patients and in healthy controls. Two heat shock genes and the CD279 gene ran higher in the white cells of symptomatic patients. Their monocytes also showed a pro-inflammatory profile, with high levels of several signaling molecules. The authors propose these genes as candidate biomarkers and a base for targeted therapy work.
Catalog record
| CREATOR | Giovanna Talarico, Andrea Franceschini, Alessandro Raveane, Paolo Falvo, Saveria Mazzara, Federica Melle, Giovanna Motta, Stefania Orecchioni, Annamaria Tenore, Giuliana Gregato, Claudia Poletti, Roberto Chiarle, Stefano Pileri, Patrizia Mancuso, Francesco Bertolini |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |