RGD peptide-conjugated polydopamine nanoparticles loaded with doxorubicin for combined chemotherapy and photothermal therapy in thyroid cancer
Donglan Yuan, Zhiqiang Lu, Xindan Xu, Wei Liu · 2024
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Description
Donglan Yuan, Zhiqiang Lu, Xindan Xu, and Wei Liu build a nanoparticle that delivers chemotherapy and heat together to thyroid tumors, in this 2024 study. The particle starts from polydopamine, a sticky, light absorbing polymer. A standard drug, doxorubicin, is attached through a bond that breaks in acid, and a targeting peptide called RGD decorates the surface.
Under near infrared light the particles heated solutions within five minutes. In dishes, the targeted particles plus light killed ninety-two percent of thyroid cancer cells. In tumor bearing mice the particles gathered at tumors, lingered there, and with light they strongly slowed tumor growth, without evident toxicity. The authors propose the design as a candidate path toward clinical use against thyroid cancer.
Catalog record
| CREATOR | Donglan Yuan, Zhiqiang Lu, Xindan Xu, Wei Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |