First preclinical SPECT/CT imaging and biodistribution of [165Er]ErCl3 and [165Er]Er-PSMA-617
Behrad Saeedi Saghez, Cristina Rodríguez-Rodríguez, Pedro Luis Esquinas, Helen Merkens, François Bénard, Valery Radchenko, Hua Yang · 2024
Read First preclinical SPECT/CT imaging and biodistribution of [165Er]ErCl3 and [165Er]Er-PSMA-617 by Behrad Saeedi Saghez, Cristina Rodríguez-Rodríguez, Pedro Luis Esquinas, Helen Merkens, François Bénard, Valery Radchenko, Hua Yang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655927.txt.
Description
Behrad Saeedi Saghez and co-workers report the first imaging and body distribution studies of a radioactive erbium isotope, in a 2024 paper. The isotope suits targeted Auger electron therapy and can be made cheaply in small medical cyclotrons. It can also stand in for other hard-to-handle metals in early tests.
The team produced the isotope, purified it, and attached it to a prostate cancer targeting molecule. The labeled compound stayed intact in blood serum for twelve hours and was taken up by prostate cancer cells. Imaging in phantoms and animals used the isotope's X-ray emissions. The work showcases its use for imaging-guided therapy studies.
Catalog record
| CREATOR | Behrad Saeedi Saghez, Cristina Rodríguez-Rodríguez, Pedro Luis Esquinas, Helen Merkens, François Bénard, Valery Radchenko, Hua Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |