Comparison of targeted next generation sequencing assays in non-small cell lung cancer patients
Ieva Drejeriene, Jurate Gruode, Saulius Cicenas, Charalambos Loizides, Alexia Eliades, Achilleas Achilleos, Elena Kypri, Kyriakos Tsangaras, Marios Ioannides, George Koumbaris, Diana Stanciute, Arnoldas Krasauskas, Philippos C Patsalis · 2024
Read Comparison of targeted next generation sequencing assays in non-small cell lung cancer patients by Ieva Drejeriene, Jurate Gruode, Saulius Cicenas, Charalambos Loizides, Alexia Eliades, Achilleas Achilleos, Elena Kypri, Kyriakos Tsangaras, Marios Ioannides, George Koumbaris, Diana Stanciute, Arnoldas Krasauskas, Philippos C Patsalis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655926.txt.
Description
A team of doctors and geneticists compared two gene testing panels for patients with the most common form of lung cancer, in a study published in 2024. Care for this cancer now depends on matching drugs to a tumor's mutations, so test quality matters. The team ran both panels on samples from thirty-one patients. Together the panels found fifty-two mutations across the group.
The most common changed genes were TP53, KRAS, and EGFR. Changes in the first two tied to shorter survival, and KRAS changes tied to one tissue type of the cancer. On the regions both panels cover, their results agreed over ninety-seven percent of the time. Each panel also caught mutations in areas the other skips, including ten found only by the broader custom panel. The authors say the added finds can shape personal treatment choices.
Catalog record
| CREATOR | Ieva Drejeriene, Jurate Gruode, Saulius Cicenas, Charalambos Loizides, Alexia Eliades, Achilleas Achilleos, Elena Kypri, Kyriakos Tsangaras, Marios Ioannides, George Koumbaris, Diana Stanciute, Arnoldas Krasauskas, Philippos C Patsalis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |