Aging and head and neck cancer insights from single cell and spatial transcriptomic analyses
Yi Pei, Zhuying Mou, Lai Jiang, Jinyan Yang, Yuheng Gu, Jie Min, Lingyi Sunzhang, Nan Xiong, Xiang Xu, Hao Chi, Ke Xu, Sinian Liu, Huiyan Luo · 2024
Read Aging and head and neck cancer insights from single cell and spatial transcriptomic analyses by Yi Pei, Zhuying Mou, Lai Jiang, Jinyan Yang, Yuheng Gu, Jie Min, Lingyi Sunzhang, Nan Xiong, Xiang Xu, Hao Chi, Ke Xu, Sinian Liu, Huiyan Luo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655923.txt.
Description
Yi Pei and eleven co-authors published this study in 2024. It explores how aging-related genes behave inside head and neck cancers, the world's sixth most common malignancy. Half of patients still die within five years, largely because the disease is caught late.
Using large public data sets plus single-cell and spatial gene-reading methods, the team mapped which cells carry which aging genes. Tumors held more monocytes and macrophages, and fewer B cells, than healthy tissue. One gene, APOE, stood out in monocytes and tracked patient outcomes closely. A risk model built from one protective gene and the patient's age predicted recurrence. Communication maps between cell types suggested how the tumor's neighborhood is rewired. The authors say aging genes could guide prognosis and personalized treatment choices. They frame the work as a map for follow-up experiments rather than a clinical tool in itself.
Catalog record
| CREATOR | Yi Pei, Zhuying Mou, Lai Jiang, Jinyan Yang, Yuheng Gu, Jie Min, Lingyi Sunzhang, Nan Xiong, Xiang Xu, Hao Chi, Ke Xu, Sinian Liu, Huiyan Luo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |