GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease
James A. Sousa, Blanca E. Callejas, Arthur Wang, Eve Higgins, Aydin Herik, Natalie Andonian, Munazza Yousuf, Pina Colarusso, Maitreyi Raman, Derek M. McKay · 2024
Read GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease by James A. Sousa, Blanca E. Callejas, Arthur Wang, Eve Higgins, Aydin Herik, Natalie Andonian, Munazza Yousuf, Pina Colarusso, Maitreyi Raman, Derek M. McKay (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655851.txt.
Description
James Sousa and co-authors find in a 2024 study that white blood cells from people with active Crohn's disease die too easily in a rust-like process. The death type is called ferroptosis, and it needs iron and fat damage. Cells from patients in remission did not share the flaw.
A drug that blocks ferroptosis saved the cells, and a fat-damage mark ran high. The weak point was a guard enzyme that needs selenium; its levels ran low in patient cells. Silencing that enzyme in healthy cells copied the flaw. Guarding gut immune cells from this death may ease the disease.
Catalog record
| CREATOR | James A. Sousa, Blanca E. Callejas, Arthur Wang, Eve Higgins, Aydin Herik, Natalie Andonian, Munazza Yousuf, Pina Colarusso, Maitreyi Raman, Derek M. McKay |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |