Essential thrombocytosis transformed AML with TP53 mutations and its clinical implications
Yang Si, Jiyuan Wang, Brett D Hambly, Yuli Wang, Yanfang Zhang, Shisan Bao · 2024
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Description
Yang Si and co-authors report in 2024 on three patients whose blood disorder turned into acute leukemia. The first illness makes too many platelets over years; rarely it flips into a fast, deadly blood cancer. A gene fault called TP53 is a known driver of that cancer, but its role in the flipped cases was little studied.
Two of the three carried the fault and held more cancer cells, the team reports. Both fared worse on a standard drug and died sooner. The third, without the fault, answered the same drug better and lived past twenty months. Heavy fault load seems to mark a harsher course, the authors suggest, so testing for it at the flip could guide how hard to treat.
Catalog record
| CREATOR | Yang Si, Jiyuan Wang, Brett D Hambly, Yuli Wang, Yanfang Zhang, Shisan Bao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |