Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice
Chang-Hang Yang, Cai-Wei Li, Yi-Yan Sie, Liang-Chieh Chen, Yu-Hsiang Yuan, Wen-Chi Hou · 2024
Read Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice by Chang-Hang Yang, Cai-Wei Li, Yi-Yan Sie, Liang-Chieh Chen, Yu-Hsiang Yuan, Wen-Chi Hou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655744.txt.
Description
Yang and co-authors test a mushroom compound and its cousins for effects tied to Alzheimer's disease, in this 2024 paper. The compound, hispolon, comes from a medicinal fungus used in Asia. It was known to fight cancer and inflammation, but its value against brain decline was unexplored.
The team screened hispolon and six related compounds in lab tests for antioxidant power, enzyme blocking, and stopping amyloid clumping. Three stood out and were checked further in nerve cells. Mice given memory-harming treatment for ten days fared better on learning tests after pre-treatment with the compounds. The authors propose the fungus compound as a lead for future foods or drugs.
Catalog record
| CREATOR | Chang-Hang Yang, Cai-Wei Li, Yi-Yan Sie, Liang-Chieh Chen, Yu-Hsiang Yuan, Wen-Chi Hou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |