Comprehensive Mendelian randomization analysis of low-density lipoprotein cholesterol and multiple cancers
Hengchang Liang, Chunling Tang, Yue Sun, Mingwei Wang, Tong Tong, Qinquan Gao, Hui Xie, Tao Tan · 2024
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Description
Hengchang Liang and co-authors test whether bad cholesterol causes five cancers in a 2024 gene study. Observational links between cholesterol and cancer are tangled by lifestyle. Mendelian randomization uses gene variants as a natural experiment to cut through that tangle.
Two genes that set cholesterol levels supplied the instruments. Their variants were checked against breast, cervical, thyroid, prostate, and colorectal cancers. With one gene's variants, higher cholesterol tracked with higher breast, prostate, and thyroid cancer risk. The same setup linked it to lower colorectal risk. Cervical results were not flagged as clear. Robustness checks and spread tests backed the main calls, the authors report.
Catalog record
| CREATOR | Hengchang Liang, Chunling Tang, Yue Sun, Mingwei Wang, Tong Tong, Qinquan Gao, Hui Xie, Tao Tan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |