Interferon-stimulated gene subtypes as key indicators of immune landscape and survival outcomes in ovarian cancer
Wanjun Luo, Dan Zhang, Zidan Lin, Junran Zhuang, Suiying Liang, Zhihong Huang, Chenfei Zhou · 2024
Read Interferon-stimulated gene subtypes as key indicators of immune landscape and survival outcomes in ovarian cancer by Wanjun Luo, Dan Zhang, Zidan Lin, Junran Zhuang, Suiying Liang, Zhihong Huang, Chenfei Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655714.txt.
Description
Genes switched on by interferon, the immune system's alarm signal, split ovarian cancer patients into two tribes with different fates, and Wanjun Luo and co-authors map the split in a 2024 study. One tribe lived significantly longer. Its tumors carried more mutations, more killer immune cells, and higher levels of the very targets that modern immune drugs block.
Hundreds of genes differed between the tribes, with the luckier one rich in immune signaling. Lab staining on a separate patient group backed the pattern. The authors propose the gene signature as a guide for choosing which patients get immune therapy first.
Catalog record
| CREATOR | Wanjun Luo, Dan Zhang, Zidan Lin, Junran Zhuang, Suiying Liang, Zhihong Huang, Chenfei Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |