Design of pseudosymmetric protein hetero-oligomers
Ryan D. Kibler, Sangmin Lee, Madison A. Kennedy, Basile I. M. Wicky, Stella M. Lai, Marius M. Kostelic, Ann Carr, Xinting Li, Cameron M. Chow, Tina K. Nguyen, Lauren Carter, Vicki H. Wysocki, Barry L. Stoddard, David Baker · 2024
Read Design of pseudosymmetric protein hetero-oligomers by Ryan D. Kibler, Sangmin Lee, Madison A. Kennedy, Basile I. M. Wicky, Stella M. Lai, Marius M. Kostelic, Ann Carr, Xinting Li, Cameron M. Chow, Tina K. Nguyen, Lauren Carter, Vicki H. Wysocki, Barry L. Stoddard, David Baker (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655659.txt.
Description
Ryan Kibler and co-authors design proteins that fake symmetry while mixing distinct chains. Their 2024 paper tackles a hard design problem: building assemblies of three or more unlike subunits whose shapes nearly match. Such near-symmetric assemblies play key roles in cell signaling and could seed new protein materials.
Their divide-and-conquer plan first redesigns single interfaces on symmetric rings. Validated rings are then recombined into mixed assemblies with near-identical backbones. The team built 19 new single-type rings and 24 mixed assemblies from them. Forms include three-chain and six-chain mixes that assemble with high shape fidelity. The matched backbones make the parts ideal blocks for larger symmetric builds, the authors argue.
Catalog record
| CREATOR | Ryan D. Kibler, Sangmin Lee, Madison A. Kennedy, Basile I. M. Wicky, Stella M. Lai, Marius M. Kostelic, Ann Carr, Xinting Li, Cameron M. Chow, Tina K. Nguyen, Lauren Carter, Vicki H. Wysocki, Barry L. Stoddard, David Baker |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |