GALNTL5, which is restricted to mouse spermatids, impairs endoplasmic reticulum (ER) function through direct interaction with ER chaperone proteins
Nobuyoshi Takasaki, Yoshihiro Koya, Mamoru Yamashita, Akihiro Nawa · 2024
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Description
Nobuyoshi Takasaki, Yoshihiro Koya, Mamoru Yamashita, and Akihiro Nawa studied in 2024 a protein called GALNTL5 that appears only in mouse spermatids, the cells that become sperm. Mice with too little of it make sperm that cannot swim well, and similar gene losses in men link to low sperm motility.
The team made a cell line that could be switched to produce GALNTL5. Lasting production harmed the endoplasmic reticulum, the cell's protein-folding workshop, by binding two chaperone proteins there and blocking their work. Protein levels fell across several cell parts, and cell shape changed. The authors argue this controlled harm helps reshape spermatids as they mature.
Catalog record
| CREATOR | Nobuyoshi Takasaki, Yoshihiro Koya, Mamoru Yamashita, Akihiro Nawa |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |