Hexamethylene amiloride induces lysosome-mediated cell death in multiple myeloma through transcription factor E3
Nianhui Yang, Zexuan Dong, Weihao Xiao, Suqi Deng, Yizhen Li, Lei Hua, Yue Li, Yingying Wu, Kexiu Huang, Wei Zhou, Hua Wang, Yonghua Li, Juan Du, Hui Zeng · 2024
Read Hexamethylene amiloride induces lysosome-mediated cell death in multiple myeloma through transcription factor E3 by Nianhui Yang, Zexuan Dong, Weihao Xiao, Suqi Deng, Yizhen Li, Lei Hua, Yue Li, Yingying Wu, Kexiu Huang, Wei Zhou, Hua Wang, Yonghua Li, Juan Du, Hui Zeng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655536.txt.
Description
Nianhui Yang and thirteen co-authors test a drug against myeloma in a 2024 paper. Multiple myeloma, a plasma cell cancer, remains largely incurable. Cancer cells pump out protons through a surface exporter to survive. A blocker of that exporter, hexamethylene amiloride, had shown anti tumor effects elsewhere.
Myeloma patients with high exporter levels fared worse, the team first showed. The blocker slowed myeloma cells and triggered their death in dishes. Patient bone marrow cells responded the same way. Part of the kill ran through a factor that boosts lysosome production. In mice, the drug shrank the disease meaningfully. It also killed cells resistant to a standard drug and boosted that drug's effect. The exporter is proposed as a fresh myeloma target.
Catalog record
| CREATOR | Nianhui Yang, Zexuan Dong, Weihao Xiao, Suqi Deng, Yizhen Li, Lei Hua, Yue Li, Yingying Wu, Kexiu Huang, Wei Zhou, Hua Wang, Yonghua Li, Juan Du, Hui Zeng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |