Metabolic dysfunction-associated steatotic liver disease and gastroesophageal reflux disease: a mendelian randomization study in European and East Asian populations
Chen’guang Su, Zheng Liao, Hewen Li, Yinxuan Pei, Zixiang Wang, Jian Li, Jinlong Liu · 2024
Read Metabolic dysfunction-associated steatotic liver disease and gastroesophageal reflux disease: a mendelian randomization study in European and East Asian populations by Chen’guang Su, Zheng Liao, Hewen Li, Yinxuan Pei, Zixiang Wang, Jian Li, Jinlong Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655479.txt.
Description
Fatty liver disease and acid reflux often appear together, but which one drives the other has been unclear. Su and co-authors used genetics to test the direction of the link in 2024, in both European and East Asian populations. Their method treats gene variants as natural instruments, letting them probe cause in both directions.
In Europeans, fatty liver did not raise reflux risk, but reflux did raise liver fat and disease risk. In East Asians, a liver enzyme tied to fatty liver showed a two-way link with reflux. A second enzyme showed no clear effect. The authors say the pattern differs by ancestry and gives fresh leads for cross-population genetic research on the two conditions.
Catalog record
| CREATOR | Chen’guang Su, Zheng Liao, Hewen Li, Yinxuan Pei, Zixiang Wang, Jian Li, Jinlong Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |