Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction
Xuhong Wang, Qi Zheng, Lingfeng Zha, Lingxue Zhang, Mingkai Huang, Si Zhang, Xuzhe Zhang, Qinlin Li, Xinglin Chen, Ni Xia, Min Zhang, Bingjie Lv, Jiao Jiao, Yuzhi Lu, Muyang Gu, Fen Yang, Jingyong Li, Nana Li, Xiang Cheng, Zihua Zhou, Tingting Tang · 2024
Read Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction by Xuhong Wang, Qi Zheng, Lingfeng Zha, Lingxue Zhang, Mingkai Huang, Si Zhang, Xuzhe Zhang, Qinlin Li, Xinglin Chen, Ni Xia, Min Zhang, Bingjie Lv, Jiao Jiao, Yuzhi Lu, Muyang Gu, Fen Yang, Jingyong Li, Nana Li, Xiang Cheng, Zihua Zhou, Tingting Tang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11655303.txt.
Description
Xuhong Wang and a large team find that an immune signal called thymic stromal lymphopoietin, or TSLP, helps the heart repair itself after a heart attack. The signal is better known from allergy and skin research, and its role in the heart was unclear. Their 2024 study caused heart attacks in mice by tying off a heart artery. They compared normal mice with mice bred to lack the receptor that receives the signal.
The signal rose in injured hearts and peaked on day seven after the attack. Mice without the receptor died more often, pumped blood worse, and scarred more, with fewer new blood vessels. Their hearts drew in more inflammatory immune cells and held fewer protective T cells. Gene readings showed that T cell activation pathways were turned down. The team reads the signal as a guardian of healing and a possible drug lead for heart failure after attacks.
Catalog record
| CREATOR | Xuhong Wang, Qi Zheng, Lingfeng Zha, Lingxue Zhang, Mingkai Huang, Si Zhang, Xuzhe Zhang, Qinlin Li, Xinglin Chen, Ni Xia, Min Zhang, Bingjie Lv, Jiao Jiao, Yuzhi Lu, Muyang Gu, Fen Yang, Jingyong Li, Nana Li, Xiang Cheng, Zihua Zhou, Tingting Tang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |