Development of a reporter feline herpesvirus-1 for antiviral screening assays
Jia Yang, Li Li, Fuqiang Xu, Fan Jia · 2024
Read Development of a reporter feline herpesvirus-1 for antiviral screening assays by Jia Yang, Li Li, Fuqiang Xu, Fan Jia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11654381.txt.
Description
Jia Yang, Li Li, Fuqiang Xu, and Fan Jia build a glowing version of a cat herpesvirus to speed the hunt for drugs against it. The virus causes upper airway disease in cats and hides for life in nerve clusters, and no specific drug exists for it. Their version carries two reporter genes: one that glows green and one shed into the fluid that shines when read.
The marked virus grew a bit slower than the wild kind, but its glow tracked its spread truly and held steady through twenty rounds of growth in cat cells. A known drug dulled the glow as expected. The team offers the virus as a clean screening tool for new antivirals.
Catalog record
| CREATOR | Jia Yang, Li Li, Fuqiang Xu, Fan Jia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |