The predominant role of FliC contributes to the flagella-related pathogenicity of ST34 S. Typhimurium monophasic variant
Yaming Hong, Qilong Hou, Hui Liu, Xiaojie Wang, Jiaojie Gu, Zhenyu Wang, Xinan Jiao, Qiuchun Li · 2024
Read The predominant role of FliC contributes to the flagella-related pathogenicity of ST34 S. Typhimurium monophasic variant by Yaming Hong, Qilong Hou, Hui Liu, Xiaojie Wang, Jiaojie Gu, Zhenyu Wang, Xinan Jiao, Qiuchun Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11654181.txt.
Description
Yaming Hong and co-authors dissect which of two tail proteins makes a rising Salmonella strain dangerous. The ST34 monophasic variant has spread worldwide, trading its second flagellin gene for drug resistance cassettes. It kept the first flagellin, FliC, and the team asks whether that keeper drives its virulence.
They built mutant strains deleting each flagellin, both, or swapping one for the other. Losing the already-absent second gene's counterpart changed little in movement or cell invasion. Removing FliC, by contrast, undercut the traits tied to disease. The verdict focuses vaccine and diagnostic attention on the flagellum the variant refused to give up, even as it armed itself against antibiotics.
Catalog record
| CREATOR | Yaming Hong, Qilong Hou, Hui Liu, Xiaojie Wang, Jiaojie Gu, Zhenyu Wang, Xinan Jiao, Qiuchun Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |