Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis
Gilson Goncalves dos Santos, Juan Miguel Jiménez-Andrade, Enriqueta Muñoz-Islas, Mariana E Candanedo-Quiroz, Andrea Gonzalez Cardenas, Bronwen Drummond, Peter Pham, Gwendalynn Stilson, Chao-Chin Hsu, Lauriane Delay, Juliana M Navia-Pelaez, Julia Paes Lemes, Yury I Miller, Tony L Yaksh, Maripat Corr · 2024
Read Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis by Gilson Goncalves dos Santos, Juan Miguel Jiménez-Andrade, Enriqueta Muñoz-Islas, Mariana E Candanedo-Quiroz, Andrea Gonzalez Cardenas, Bronwen Drummond, Peter Pham, Gwendalynn Stilson, Chao-Chin Hsu, Lauriane Delay, Juliana M Navia-Pelaez, Julia Paes Lemes, Yury I Miller, Tony L Yaksh, Maripat Corr (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11654167.txt.
Description
Gilson dos Santos and co-authors dissect why arthritis pain outlives arthritis inflammation, using a mouse model where the immune receptor TLR4 is deleted from chosen cell types. Their 2024 study uses serum-transfer arthritis, in which pain sensitivity persists after swelling resolves in normal mice but not in mice lacking TLR4.
After the arthritic serum, normal mice grew nerve fibers in the joint lining and lost trabecular bone density, changes absent without the receptor. Deleting TLR4 in immune cells of the bone marrow line, or in the spinal cord's microglia, partly reversed the chronic pain; deleting it in sensory neurons did not. One microglia-targeted deletion softened the arthritis itself. The map that emerges is distributed: a pain that lives in joint, bone, and cord, gated by one receptor. For rheumatoid patients whose pain survives remission, that map suggests where to aim.
Catalog record
| CREATOR | Gilson Goncalves dos Santos, Juan Miguel Jiménez-Andrade, Enriqueta Muñoz-Islas, Mariana E Candanedo-Quiroz, Andrea Gonzalez Cardenas, Bronwen Drummond, Peter Pham, Gwendalynn Stilson, Chao-Chin Hsu, Lauriane Delay, Juliana M Navia-Pelaez, Julia Paes Lemes, Yury I Miller, Tony L Yaksh, Maripat Corr |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |