Revealing novel CD8+ T-cell epitopes from the H5N1 avian influenza virus in HBW/B1 haplotype ducks
Wanlin Jiao, Yingyi Chen, Zimin Xie, Li Zhao, Shanyao Du, Mulin Ma, Ming Liao, Manman Dai · 2024
Read Revealing novel CD8+ T-cell epitopes from the H5N1 avian influenza virus in HBW/B1 haplotype ducks by Wanlin Jiao, Yingyi Chen, Zimin Xie, Li Zhao, Shanyao Du, Mulin Ma, Ming Liao, Manman Dai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11653964.txt.
Description
Wanlin Jiao and co-authors find the exact virus fragments that duck killer T cells recognize in bird flu, in this 2024 paper. Ducks with the B1 gene type fight H5N1 well, and their CD8 cells lead the defense. Which peptides those cells target was mostly unknown.
Infected ducks showed surging CD8 shares and defense gene activity a week in. From one hundred nine predicted fragments, twelve proved able to wake memory cells. Five were shared across H5N1 and four other flu strains. The catalog steers design of a universal T-cell vaccine for poultry. The catalog steers design of a universal T-cell vaccine for poultry flocks facing repeated flu threats.
Catalog record
| CREATOR | Wanlin Jiao, Yingyi Chen, Zimin Xie, Li Zhao, Shanyao Du, Mulin Ma, Ming Liao, Manman Dai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |