D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation
Honglin Liu, Huimin Huang, Zhen Huang, Yingxuan Chen, Deyou Tan, Xiaoni Wang, Xiaoni Pang, Shuwen Chen, Lianhui Liang, Haihui Yang · 2024
Read D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation by Honglin Liu, Huimin Huang, Zhen Huang, Yingxuan Chen, Deyou Tan, Xiaoni Wang, Xiaoni Pang, Shuwen Chen, Lianhui Liang, Haihui Yang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11653942.txt.
Description
Honglin Liu and nine co-authors show that a lab chemical, D609, blunts the immune fight against tuberculosis by hampering the cells that present the germ to the immune system. Dendritic cells collect germ parts and show them to T cells, starting the attack. D609 blocks a fat-splitting enzyme in those cells. Their 2024 study gave the blocker to mice before infecting them with the tuberculosis strain H37Rv, then counted bacteria in lung and spleen and scored tissue damage.
The design reads the enzyme's role by its absence: if blocking it weakens defense, the enzyme normally helps. That insight warns against careless use of such blockers and maps a control point in immunity. The authors track germ counts, tissue pictures, and blood signals together. Their question is basic but pointed: which cell functions does tuberculosis control depend on?
Catalog record
| CREATOR | Honglin Liu, Huimin Huang, Zhen Huang, Yingxuan Chen, Deyou Tan, Xiaoni Wang, Xiaoni Pang, Shuwen Chen, Lianhui Liang, Haihui Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |