Interrelationships Between Inflammatory Score, Delayed Cerebral Ischemia and Unfavorable Outcome in Patients with aSAH: A Four-Way Decomposition
Peng Zhang, Haiyang Zhu, Xinbo Li, Yiwei Qian, Yehao Zhu, Weizhong Zhang, Zhiyuan Yan, Haoqi Ni, Zhongxiao Lin, Xiao Lin, Zequn Li, Qichuan Zhuge, Bo Zeng · 2024
Read Interrelationships Between Inflammatory Score, Delayed Cerebral Ischemia and Unfavorable Outcome in Patients with aSAH: A Four-Way Decomposition by Peng Zhang, Haiyang Zhu, Xinbo Li, Yiwei Qian, Yehao Zhu, Weizhong Zhang, Zhiyuan Yan, Haoqi Ni, Zhongxiao Lin, Xiao Lin, Zequn Li, Qichuan Zhuge, Bo Zeng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11653884.txt.
Description
Peng Zhang and co-authors build an inflammation score to forecast harm after a brain aneurysm bursts. The bleeding, called aneurysmal subarachnoid hemorrhage, can be followed days later by delayed cerebral ischemia, a second wave of brain injury tied to poor outcomes. The team used machine learning to pick blood markers and combined four of them into one score for 368 patients.
The score tracked both the delayed injury and poor outcome on its own. A four-way decomposition then split how the score's effect flows: part acts directly, part passes through the delayed injury, and a large part comes from the two reinforcing each other. Adding the score to an existing forecast model sharpened its accuracy and sorting power. The authors present the score as a cheap, blood-based way to flag high-risk patients early and to understand how inflammation and delayed injury combine.
Catalog record
| CREATOR | Peng Zhang, Haiyang Zhu, Xinbo Li, Yiwei Qian, Yehao Zhu, Weizhong Zhang, Zhiyuan Yan, Haoqi Ni, Zhongxiao Lin, Xiao Lin, Zequn Li, Qichuan Zhuge, Bo Zeng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |